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Unified Journal of medicine and Medical Sciences

October 2016 Vol 2(1), pp. 001-009

Copyright © 2016 Unified Journals

Original Research Article

Proactive Therapeutical Modulation of the Postoperative Intraperitoneal Adhesions- the Efficacy of the Collagen-based Biomaterials (simple and composite)

Simona Bobic1,2*, Vlad Denis Constantin1,2, Vlad Andrei Budu3,Bogdan Socea 1,2 , Gheorghe H Popescu4 and Elvira Nica 5

1Surgery Department, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania
2Surgery Department, "SfântulPantelimon" Emergency Clinical Hospital, Bucharest, Romania
3Prof. Dr. .D Hociot?" Phonoaudiology and ENT Surgery Hospital, Bucharest, Romania
4Dimitrie Cantemir" University, Bucharest, Romania
5Public Administration and Management Faculty, Academy of Economic Studies, Bucharest, Romania

Corresponding Author's Email: simona.bobic@yahoo.ca

Accepted 5th September, 2016.


Abstract


Introduction: Postoperative peritoneal adhesions can cause severe complications, preventing methods being of a great importance, bioabsorbable membranes being able to prevent localized adhesion.
Material and method: The study was a single-center prospective, randomized controlled investigation, safety and efficacy of collagen-based sponge in the study group being compared to no anti-adhesion treatment in a parallel control-group, with blinded evaluation of primary endpoints.
Results: A significant reduction was observed in adhesion severity when the collagen sponge was applied in the laparotomy groups. Collagen sponge serves as a temporary barrier, separating apposing peritoneal surfaces throughout the healing process, being fully biodegraded and resorbed over approximately 3 to 5 weeks.
Discussion and conclusions: The collagen material showed good handling and was able to conform readily to the tissue contours. At the time of reintervention, in the selected cases, examination of the peritoneal cavity showed fewer adhesions, better healing of the injured surface and little or no fibrotic reaction in the cases receiving collagen-based sponge as an adhesive barrier.

Keywords: collagen sponge, peritoneal adhesion, prevention.

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Cite This Article

Simona Bobic et al., Proactive Therapeutical Modulation of the Postoperative Intraperitoneal Adhesions- the Efficacy of the Collagen-based Biomaterials (simple and composite). Unified Journal of Medicine and Medical Sciences. 2(1) 2016 pp. 001-009.




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